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The DNA Structure That Only Appears When the Cell Is Alive What if DNA doesn’t always look like the classic double helix? Enter i-Motif DNA — a strange, folded DNA structure that forms inside living human cells, but only under very specific conditions. Unlike the familiar double helix, the i-motif twists into a four-stranded knot, held together by interactions between cytosine bases. For years, scientists thought it could only exist in test tubes under acidic conditions — too unstable to survive
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The DNA Structure That Only Appears When the Cell Is Alive What if DNA doesn’t always look like the classic double helix? Enter i-Motif DNA — a strange, folded DNA structure that forms inside living human cells, but only under very specific conditions. Unlike the familiar double helix, the i-motif twists into a four-stranded knot, held together by interactions between cytosine bases. For years, scientists thought it could only exist in test tubes under acidic conditions — too unstable to survive
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Inside your cells, DNA is constantly being monitored. Specialized proteins scan DNA strands for structural problems such as breaks or chemical changes. When damage is detected, these sensors trigger repair systems that pause cell activity and recruit DNA repair enzymes. This biological surveillance system helps protect genetic information and prevents mutations from spreading during cell division. This process is part of the cell’s DNA damage response.
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