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Chronic granulomatous disease
Pathogenesis: X-linked recessive mutation of NADPH oxidase Impaired respiratory burst & ↓ reactive oxygen species → inhibition of phagocytic intracellular killing Clinical features: Recurrent infections with catalase-positive bacteria & fungi Staphylococcus aureus, Burkholderia (Pseudomonas) cepacia, Serratia marcescens, Nocardia ...
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