In the span of a week, the San Francisco 49ers are watching their running backs drop like flies. Superstar Christian ...

When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, a day after the team's dominant 38-13 victory over the Chicago Bears. He shared several injury updates ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

SportsLine's model simulated Chicago Bears vs. San Francisco 49ers 10,000 times and made its Week 14 NFL picks, predictions ...

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, playing 88% of the offensive snaps. In contrast, Jordan Mason has seen just 8% ...

With Christian McCaffrey on the shelf, the 49ers will turn to RB Isaac Guerendo, and he will deliver in Week 14 against the Bears!

Both of these teams are nowhere near where they'd like to be this season, but with one finding a rejuvenated energy to ...

Returning to the field with Super Bowl expectations after falling just short of the Kansas City Chiefs earlier in the ...

San Francisco 49ers quarterback Brock Purdy addressed the team's heightened sense of urgency following recent challenges and shared his thoughts on the upcoming Week 14 matchup against the Chicago ...

Head coach Kyle Shanahan shared a final injury report on T Trent Williams, DL Nick Bosa and other 49ers players ahead of the ...