Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

City, county and state officials are preparing for whatever the weather system has in store for Western New York.

The 49ers are struggling at 5-6. They have a tough game in Buffalo on Sunday night. A loss would further complicate their path to the postseason. So how is the current vibe in the locker room?

Simpson carried the ball 29 times against the Lions and set a new NFL record with 273 rushing yards, breaking his own record ...

Milano practiced without a red non-contact jersey for the first time since his bicep injury in August and was listed on the ...

Buffalo Bills defensive tackle (and fashion icon) Jordan Phillips again broke out his fan-favorite winter coat during ...

The Buffalo Bills are set to have a classic snow game matchup against the San Francisco 49ers in Orchard Park.

The New York Giants drafted Barkley with the second overall pick in the 2018 draft. He became the 2018 Offensive Rookie of ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

LB Fred Warner, WR Deebo Samuel Sr., RB Christian McCaffrey and DL Nick Bosa identified key areas for improvement as the team ...

The Buffalo Bills have opened the 21-day practice windows of offensive tackle Tylan Grable and defensive tackle DeWayne ...