Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

City, county and state officials are preparing for whatever the weather system has in store for Western New York.

The 49ers are struggling at 5-6. They have a tough game in Buffalo on Sunday night. A loss would further complicate their path to the postseason. So how is the current vibe in the locker room?

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

Milano practiced without a red non-contact jersey for the first time since his bicep injury in August and was listed on the ...

Quarterback Tua Tagovailoa hopes to continue his hot streak in the cold when he and the Miami Dolphins visit Lambeau Field ...

Around 10:50 p.m., Route 20A, also known as Big Tree Road, will convert to two-lane, one-way traffic eastbound away from the ...

Buffalo, Kansas City and Detroit have a chance to punch their playoff tickets in Week 13.The Bills (9-2) have the least ...

Brock Purdy was listed as limited for Wednesday's practice by San Francisco 49ers head coach Kyle Shanahan, suggesting some ...

The Buffalo Bills are set to have a classic snow game matchup against the San Francisco 49ers in Orchard Park.

After dropping two straight games and falling to 5-6 on the season, the San Francisco 49ers will now prepare for a contest ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...