The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock Purdy. Backup quarterback Brandon

After that, there is no significant NFL talent on the 49ers roster, while the edges are equally deficient in both depth and run-stopping abilities. For that reason, the Bills may pursue interior runs early and often while San Francisco struggles to find ...

The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with potentially 2-3 feet of additional

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five keys to victory for the Bills as they welcome the 49ers into Orchard Park,

The Buffalo Bills played the Kansas City Chiefs in their last game before heading into the bye week. They pulled off the upset and handed the Chiefs their first loss of the 2024 NFL season by a score of 30-21.

The San Francisco 49ers and Buffalo Bills are set to face-off in the Week 13 edition of Sunday Night Football. Before the season began, this matchup was circled

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

The Bills are 9-2, their best start since 1992, and with a win would clinch their fifth straight AFC East title.

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at 5:20 p.m. PT. The Bills are currently six-point favorites. Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting...