This Notice of Change announces the participation of the National Institute of Neurological Disorders and Stroke (NINDS) in the Notice of Funding Opportunity,"Bioengineering Research Grants (BRG) (R01 ...
The FDA has given the nod to two blood tests for Alzheimer’s disease. On August 20 they cleared C2N’s Precivity AD2 test. On August 24, they announced that Roche’s Elecsys p-tau217 passed muster. Both ...
Not all astrocyte lipid droplets are created equal. In the August 19 Nature Communications, scientists led by Priyanka Narayan at the National Institutes of Health in Bethesda, Maryland, report that ...
Microglia in human brain are descended from progenitor cells that arose in the embryonic yolk sac—but does this remain the case life-long? Two new papers argue that in late adulthood, these original ...
Scientists might have happened upon a new Alzheimer’s pathology. In the July 29 Nature Neuroscience, researchers led by Vilhelm Bohr at the National Institutes of Health, Baltimore, and Paul Robbins ...
Autosomal-dominant mutations in the progranulin gene halve expression of this critical lysosomal protein, causing an aggressive, early onset form of frontotemporal dementia. Replacement of the lost ...
Scientists have tried several ways to restrain tau pathology, with varied success. Here’s a new one: alter splicing of the tau gene, MAPT, so that neurons make less of the aggregation-prone 4R isoform ...
How do anti-amyloid antibodies interact with tau pathology? This is still an open question. At last month’s AAIC in London, several scientists addressed how antibodies affect tangles, and how tangles ...
Lysosomal dysfunction and neurodegeneration are two processes that often go hand in hand. Now, companion papers in the August 11 Immunity help explain why. Despite focusing on two different ...
Limbic-predominant age-related TDP-43 encephalopathy commonly co-occurs with Alzheimer’s disease. At this year's AAIC, held July 12–15 in London, five research groups presented new findings on what ...
Summary These transgenic mice express a chimeric mouse/human APP carrying the Swedish mutation under the control of the mouse prion protein promoter. This line, C3-3, was generated in parallel with ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results