GutOpinion

Accessibility versus efficacy: interpreting the non-inferiority trial of digital hypnotherapy in IBS

Snijkers and colleagues should be congratulated for completing a multicentre, three-arm randomised trial of gut-directed ...
Gut

Replication of protein associations is not external validation of a fixed mortality score

Diambra and colleagues1 integrated metabolic dysfunction-associated steatotic liver disease phenotypes with proteomics to derive a four-protein mortality score (PS4: FTCD, FABP1, ADGRG1 and GAST). We ...
Gut

From pressure to prognosis: establishing a common language for portal hypertension in advanced chronic liver disease

Risk stratification in compensated advanced chronic liver disease has traditionally been based on the identification of ...
gut.bmj

Establishment of standardised SLA/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence, and clinical characteristics

Background: Antibodies to soluble liver antigen/liver pancreas (SLA/LP) are specific markers of autoimmune hepatitis. Their target antigen has recently been cloned. Aims: To establish standardised ...
gut.bmj

Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps

1 Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China 2 Department of Surgery, ...
gut.bmj

Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study

Background and aims: Melatonin, a sleep promoting agent, is involved in the regulation of gastrointestinal motility and sensation. We aimed to determine if melatonin was effective in improving bowel ...
gut.bmj

Management of acute severe ulcerative colitis

Correspondence to Dr Gert Van Assche, University Hospital Leuven, Centre for GI research, University of Leuven, B-3000 Leuven, Belgium; gert.vanassche{at}uz.kuleuven.ac.be Acute severe ulcerative ...
gut.bmj

Clinical risk factors of colorectal cancer in patients with serrated polyposis syndrome: a multicentre cohort analysis

Correspondence to Dr Evelien Dekker, Department of Gastroenterology and Hepatology, Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands; e.dekker{at}amc.uva.nl Objective ...
gut.bmj

SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation

Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal tumour with limited treatment options. Here, we identified syndecan binding protein (SDCBP), also known as syntenin1, as a novel ...
gut.bmj

Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease

1 Celiac Center and Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA 2 Department of Pathology, Beth Israel Deaconess Medical Center, Boston, ...
gut.bmj

Purification, biochemical, and immunological characterisation of a major food allergen: different immunoglobulin E recognition of the apo- and calcium-bound forms of carp ...

Dr R Valenta, Molecular Immunopathology Group, Department of Pathophysiology, Vienna General Hospital, University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria BACKGROUND Almost 4% of the ...
gut.bmj

Association between duodenal bile salts and gastric emptying in patients with functional dyspepsia

We read with interest the study by Higuchi et al , which identified mechanisms of increased satiation in Cyp8b1−/− mice via slowed gastric empting.1 Following data showing that deleting Cyp8b1, which ...