Deebo Samuel probably is the most disappointing player on the most disappointing team in the NFL through 12 weeks. Despite ...

One San Francisco 49ers star has been dealing with more pain than was previously known for most of the season.

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4.

Weather looks set to play a role in the Buffalo Bills' Week 13 matchup with the San Francisco 49ers.

Fred Warner revealed for the first time Wednesday that he's been playing through a fractured bone in his ankle that he ...

Even after Christian McCaffrey’s return to the field, the story surrounding his Achilles injury and the impact it’s having on ...

San Francisco isn't a stranger to taking chances on former starters. The 49ers had Sam Darnold on the roster last year and he ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...