Our Louisville vs. Mississippi prediction for Sunday, Sept. 6 back the Cardinals as underdogs against a Rebels team with major questions entering Week 1.

Sunday’s college football slate features three marquee matchups. Here are our best bets for Notre Dame vs. Wisconsin, Ole Miss vs. Louisville and Washington State vs. Washington.

Expectations are high heading into UofL football coach Jeff Brohm's fourth year. Here are the best- and worst-case scenarios for the Cards in 2026.

No. 19 SMU and Florida State take center stage on Labor Day. Led by star quarterback Kevin Jennings, the ACC active leader in career passing yards (7,709) and career total yards (8,267), SMU finds itself in the preseason top 20 for the second straight year.

Ole Miss football plays Louisville in Week 1 of the 2026 college football season. Who wins? See our picks and predictions.

Ahead of the anticipated Week 1 matchup, the Ole Miss On SI staff makes its game picks between the Rebels and Cardinals. Kickoff is set for 6:30 p.m. CT on ABC.

The city's 24th annual WorldFest, Louisville's premier international festival, is returning to Louisville for Labor Day weekend.

GE Appliance Park will receive $1B in upgrades as the Louisville manufacturing campus expands laundry production and reshoring capacity.

The Ole Miss Rebels will have a challenging opponent in the season opener.