Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

After dropping two straight games and falling to 5-6 on the season, the San Francisco 49ers will now prepare for a contest ...

Around 10:50 p.m., Route 20A, also known as Big Tree Road, will convert to two-lane, one-way traffic eastbound away from the ...

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

Sunday could be the day Douglas has been waiting for -- because Milano is closing in on his return. The 30-year-old was a ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

There is a High Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the San Francisco 49ers ...

The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...