This study elucidates the pivotal role of neutrophil extracellular traps (NETs) in orchestrating immune-mediated renal fibrosis through macrophage-CD8⁺ T cell crosstalk. In obstructive nephropathy, ...

NETs promote macrophage expression of T-cell chemokines and subsequently facilitate cytotoxic CD8+ T cell infiltration and granzyme B production, which drives kidney fibrosis in obstructive ...

Version of Record: This is the final version of the article. The concept that trained immunity, as defined, can be beneficial to subsequent immune challenges is important in the broad context of ...

The effects of sargramostim and filgrastim on hematopoietic cells are described. Filgrastim is a lineage-specific colonystimulating factor (CSF), mainly affecting neutrophils. In addition to enhancing ...

Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for hepatocellular carcinoma (HCC) due to drug resistance. Emerging therapies such ...

Mice are essential for studying immune responses, but functional differences between human and murine systems limit their utility, particularly for neutrophils. Humanized mice with a human immune ...

This valuable study advances the understanding of granuloma formation by identifying a key chemokine receptors in containing infection by a specific species of bacteria. The evidence supporting this ...

Introduction: An impaired cardiac macrophage migration inhibitory factor (MIF) signaling in aging during ischemia and reperfusion (I/R) can be rescued by a MIF agonist, MIF20. Alterations in cardiac ...