Among patients with AQP4-NMOSD, those with cardiovascular comorbidities exhibited higher annual optic neuritis relapses than those with autoimmune comorbidities (mean, 1.06 ± 3.33 vs 0.49 ± 0.98 ...

AQP4-IgG: Autoantibodies targeting aquaporin-4 water channels, primarily associated with neuromyelitis optica. MOG-IgG: Autoantibodies directed against myelin oligodendrocyte glycoprotein ...

Patients with anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive neuromyelitis optica spectrum disorder (NMOSD) show the best visual prognosis and the shortest recovery time of 1 to 2 ...

The OCT showed reduced inner nuclear layer thickness in AQP4-NMOSD with comorbidities (B = −1.52, P = 0.047), more marked in those with CVC/RF (B = −2.96, P = 0.009). Investigators concluded that ...

Results 27.6% (8/29) were positive for MOG antibodies and 3.4% (1/29) were positive for AQP4. Among the eight patients with MOG antibodies, five had optic pain (p=0.001) and three had prodromal ...

Acute optic neuritis (ON) typically presents with ocular pain and low visual acuity (VA), and there is a risk of permanent vision loss if ON is not managed properly.1 ON may be the first symptom of ...

A recent study reported that combined ganglion cell and inner plexiform layer loss was independent of optic neuritis attacks in AQP4+NMOSD.38 Another study also showed subclinical neurodegeneration as ...

The water channel aquaporin 4 (AQP4) is abundantly expressed in the brain, and also in lung and kidney. Previous studies have suggested that there are at least two AQP4 mRNA. The two mRNA encode ...

Of adult patients with MS, 50% will develop optic neuritis during the course of MS, and it is the first clinical symptom in 20% of patients. In a small retrospective series of children with MS who ...

FLOYD COUNTY, Ind. (WDRB) — A company in the process of installing fiber optic cables in a southern Indiana neighborhood has been ordered to immediately stop all operations. The stop-work order ...

Blocking AQP4 with the selective inhibitor TGN-020 nullified these benefits, supporting the interpretation that they can be attributed to improved glymphatic function. Additionally, the authors found ...

Columbia scientists have found that boosting the performance of a self-cleansing system in the brain helps flush amyloid and tau toxins from the brains of mice and improves the animals' cognition.