San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

The San Francisco 49ers will take on the Buffalo Bills in the Week 13 edition of NBC's "Sunday Night Football." What to know ...

The Bills return from the bye for a primetime showdown with the 49ers in NFL Week 13 on Sunday, Dec. 1 at Highmark Stadium.

The Buffalo Bills tabbed a tight end and a quarterback as gameday elevations for the Sunday Night Football affair against the ...

Snow has blanketed Orchard Park, New York, where the Buffalo Bills will play the San Francisco 49ers on Sunday Night Football ...

The Buffalo Bills have shared a clip of intense snow covering Highmark Stadium ahead of their game with the San Francisco ...

The San Francisco 49ers saw their playoff chances plummet following consecutive losses to the Seattle Seahawks and Green Bay ...

Coming into the 2024 NFL season, it wouldn't have been out of the ordinary to find a Super Bowl prediction featuring the ...

One of the best receivers in the league will be on display when George Kittle and the San Francisco 49ers visit the Buffalo ...

Four NFL games on Thanksgiving and Black Friday kicked off Week 13 action, and the full schedule continues on Sunday, Dec. 1, ...

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...