Objective This study aimed to compare 25-hydroxyvitamin D (25-(OH)D) levels and peripheral lymphocyte subsets between ...
Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving dysregulated innate and adaptive immunity, with autoreactive B and T cells being central to its pathogenesis.
Background XmAb5871 is a humanized anti-CD19 antibody Fc-engineered for increased affinity to FcgammaRIIb. Co-ligation of CD19 and FcgammaRIIb inhibits B lineage cells key to lupus pathogenesis. This ...
Introduction Lupus nephritis (LN) exhibits substantial clinical and pathological heterogeneity. We aimed to define proteomics-based molecular subtypes of LN and identify candidate biomarkers for ...
Objectives CD163 is a macrophage-associated scavenger receptor shed during inflammatory activation, resulting in measurable soluble CD163 in serum (s) and urine (u). Elevated levels have been reported ...
Background Proliferating cell nuclear antigen (PCNA) antibodies are a rare type of antinuclear antibodies (ANA), historically considered highly specific for systemic lupus erythematosus (SLE). Recent ...
Purpose Systemic lupus erythematosus (SLE) is an IgG-mediated autoimmune disease. Nipocalimab, which is in clinical development for the treatment of SLE, targets the IgG binding site on neonatal Fc ...
Background Spontaneous murine models of lupus-like disease are used to study the pathogenesis and genetic causes of SLE. Environmentally-induced lupus models (i.e. pristine-induced) are also valuable ...
Objective Epidemiologic data on falls in the population with systemic lupus erythematosus (SLE) remain sparse. We estimated ...
Objective To characterise the safety and efficacy of anifrolumab in active lupus nephritis (LN) through year 2 of the phase II randomised, double-blind Treatment of Uncontrolled Lupus via the ...
Case 1: A 35-year-old female with SLE and planning IVF pregnancy In October 2024 a 35-year-old female with systemic lupus erythematosus (SLE) was reviewed for planning of in vitro fertilization (IVF) ...
22 Historical aspects of B-cell depletion in SLE (8 October, 2025) ...
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