eLife2h
Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial
Kaplan–Meier curves showed that extended adjuvant pyrotinib administered after trastuzumab-based adjuvant therapy provides a promising survival benefit in patients with high-risk HER2-positive breast ...
eLife5h
Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism models
A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...
eLife1d
A-to-I RNA editing of CYP18A1 mediates transgenerational wing dimorphism in aphids
Binding of miR-3036-5p to CYP18A1 can be prevented by an A-to-I RNA editing, thus elevating CYP18A1 expression, decreasing 20E titer, and finally regulating the wing dimorphism of offspring in aphid.
eLife1d
Neuronal Signaling: At the crossroads of calcium signaling, protein synthesis and neuropeptide release
By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.
eLife1d
Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia
This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...
eLife1d
Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Because chemogenetic control relies on DREADD expression levels, understanding and quantifying the temporal dynamics of their expression is crucial for planning long-term experiments in monkeys. In ...
eLife1d
A network regularized linear model to infer spatial expression pattern for single cell
The study is useful for advancing spatial transcriptomics through its novel regression-based linear model (glmSMA) that integrates single-cell RNA-seq with spatial reference atlases, though its ...
eLife1d
MMP21 behaves as a fluid flow transported morphogen to impart laterality during development
Laboratory of Human Genetics & Therapeutics, Smart Health Initiative, Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST ...
eLife1d
Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryoEM and MD simulations
This important study shows, for the first time, the structure and snapshots of the dynamics of the full-length soluble Angiotensin-I converting enzyme dimer. The combination of structural and ...
eLife1d
Heat Stress Induced Bacterial Tolerance against Phage Facilitates the Evolution of Resistance
This important study analyzes the effect of heat treatment on phage-bacterial interactions and convincingly shows that prior heat exposure alters the bacterial cell envelope, enhancing persistence and ...
eLife2d
Nora virus proliferates in dividing intestinal stem cells and sensitizes flies to intestinal infection and oxidative stress
This important study shows that the Nora virus, a natural Drosophila pathogen that also persistently infects many laboratory fly stocks, infects intestinal stem cells (ISCs), leading to a shorter life ...
eLife2d
Lens Development: Bringing signaling complexity into focus
A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.