We focus this analysis on the initiation of salt-induced increases in blood pressure because we are interested in how increases in salt intake cause increased blood pressure from the outset and why ...

The American Heart Association’s 2025 Adult Basic Life Support Guidelines build upon prior versions with updated recommendations for assessment and management of persons with cardiac arrest, as well ...

A 74-year-old man with a history of chronic obstructive pulmonary disease, prostate cancer (treated with surgery), and hypertension, which is being treated with an angiotensin-converting enzyme ...

The role of hemoglobin and myoglobin in the cardiovascular system is well established, yet other globins in this context are poorly characterized. Here, we examined the expression and function of ...

As the name atherosclerosis implies, mature plaques typically consist of two main components: soft, lipid-rich atheromatous “gruel” and hard, collagen-rich sclerotic tissue (Fig 1A). The sclerotic ...

BACKGROUND: Cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in the ECM (extracellular matrix) and cardiomyocyte structure. These alterations critically ...

Afterload reduction is a cornerstone in the management of patients with heart failure (HF) and reduced ejection fraction. However, arterial load and the effect of HF therapies on afterload might vary ...

Background— Arterial hypertension is one of the major diseases in industrial countries and a major cause of mortality. One of the main vascular factors responsible for the relaxation of blood vessels ...

First, there was Robert Furchgott. 1 He simply and brilliantly demonstrated that endothelial cells play a pivotal role in relaxations evoked by acetylcholine in isolated arteries, and do so by ...

We previously demonstrated that conditional overexpression of neuronal nitric oxide synthase (nNOS) inhibited L-type Ca 2+ channels and decreased myocardial contractility. However, nNOS has multiple ...

Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic ...

Background— Early outcomes after tricuspid valve replacement in young children are ill defined. The experience of the Pediatric Cardiac Care Consortium (45 centers, 1984 to 2002) was reviewed to ...