Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for ...

The 49ers (5-7) are alone in last place in the NFC West for the first time since the 2020 season ended. On the heels of this ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian ...

The Bills are a Super Bowl contender and the 49ers somehow probably aren’t even a playoff team. That’s how Sunday night’s ...

It's the Bills vs the 49ers in Week 13 of the 2024 NFL season. Here's how to watch, including time, channel, TV schedule and ...

Buffalo (9-2) brings a six-game winning streak into a matchup with San Francisco (5-6) on Sunday, December 1, 2024 at ...

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

A pair of Super Bowl hopefuls from each conference meet up on Sunday, Dec. 1 to close out the NFL schedule for the day with ...

The Buffalo Bills (9-2) will try to build on a six-game winning streak when they host the San Francisco 49ers (5-6) on Sunday ...