Israel's overnight missile strike was the largest attack on the Islamic Republic since the Iran-Iraq war of the 1980s.

The military strikes jolted investors, raising concerns that a broader Mideast conflict would disrupt the world’s energy supplies.

American citizens in Israel are strongly advised to limit internal travel and to maintain a high level of situational awareness. Iran remains under a longstanding "Level 4: Do Not Travel" advisory due to risks of terrorism, kidnapping, wrongful detention, and civil unrest.

Ben Rhodes, former deputy national security advisor, talks with Jen Psaki about the awkwardness of the Trump administration trying to distance itself from Israel's attack on Iran, and what it means about Donald Trump's status that Israel's attack came while Trump was attempting to negotiate a new nuclear deal with Iran.

Iran once ridiculed Israeli Prime Minister Benjamin Netanyahu as the boy who cried wolf for his constant public warnings about Tehran's nuclear programme, and his repeated threats to shut it down, one way or another.

Explosions reported in capital Tehran as Israeli Defence Minister announces "pre-emptive strikes" and announces state of emergency