Imaging of single mRNA molecules undergoing translation provides insights into the regulation of protein synthesis. Current approaches for studying translation measure protein synthesis generated from ...

Synonymous codons are used non-randomly in the transcriptome to shape multiple aspects of translation. Optimal codons are associated with more efficient translation and correspond to cognate tRNA ...

In a recent study published in Nature, a group of researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into messenger ribonucleic acids (mRNAs) affects ribosomal ...

Think of life as a house: if DNA molecules are blueprints, then messenger RNAs (mRNAs) are orders, describing the required parts (proteins) and when they should arrive. But putting in many orders ...

A recent study posted to the bioRxiv* pre-print server investigated the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to inhibit the human immune response against viral ...

Neurodegenerative diseases are commonly adult-onset conditions characterized by degeneration of specific neuronal populations. Familial forms are caused by mutations in single genes, but most patients ...

Delivery of genetic molecules such as mRNA into cells is vital with important applications such as vaccine development. Various agents have been developed for mRNA delivery. However, conventional mRNA ...

mRNA, widely known from the COVID-19 vaccine, is not actually a “therapeutic agent,” but a technology that delivers the blueprint for functional proteins into the body so that induces therapeutic ...

Our understanding of how messenger RNAs are translated into proteins is challenged by new research published today in the Open Access journal Journal of Biology. The study suggests that EF-G, the ...

Takeda Pharmaceutical is collaborating with Anima Biotech to discover and develop small-molecule drugs for three neurological disease targets, including Huntington’s disease. Anima seeks to find ...