Depression is a complex and deeply personal experience. While almost everyone has periods of sadness, low mood or grief, ...

Patients with type 2 diabetes often have comorbid major depressive disorder, but the underlying neurobiological substrates are still poorly understood. The goal of this study was, therefore, to ...

The core experiences of depression — changes in energy, activity, thinking, and mood — have been described for more than 10,000 years. The word “depression” has been used for about 350 years. Given ...

Does depression have some hidden trigger? Although depression most often arises in response to some kind of defeat, depression can seem to arise out of the blue, for no obvious reason. It may even ...

Since the 1960s, researchers have postulated that major depression stems from disruptions in the serotonin neurotransmitter system, but the evidence for that idea, though plentiful, was indirect. In ...

Depression is characterized by a persistent low mood that can affect quality of life. If symptoms usually only occur in the winter months, it may be seasonal affective disorder (SAD), or major ...

When drugs like Prozac were first introduced in the late 1980s, the leading theory behind their market success was that depressed people lacked serotonin, a key brain chemical. Called the “chemical ...

Depression is a state of unhappiness and hopelessness - a psychiatric disorder manifested by persistent feelings of dejection, lack of energy, poor concentration and sometimes suicidal thoughts. There ...