The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC). Let's analyze BetM

Coming into the 2024 NFL season, it wouldn't have been out of the ordinary to find a Super Bowl prediction featuring the Buffalo Bills or San Francisco 49ers, or both. Josh Allen's AFC squad entered looking for its sixth straight playoff appearance.

After that, there is no significant NFL talent on the 49ers roster, while the edges are equally deficient in both depth and run-stopping abilities. For that reason, the Bills may pursue interior runs early and often while San Francisco struggles to find ...

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five keys to victory for the Bills as they welcome the 49ers into Orchard Park,

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

It was one of the best plays of the NFL season, and by the time he reached the celebration ... show for any of the voters who may be watching, as the Bills host the San Francisco 49ers. This is the fifth time the Bills are playing in prime-time this ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got destroyed by the Green Bay Packers. Granted Brock Purdy didn't play, but the 49ers didn't look like an NFC contender.

Buffalo Bills offensive stars prepare to shine against the San Francisco 49ers' struggling defense in a critical AFC-NFC clash at Highmark Stadium.

The Buffalo Bills will look to clinch the AFC East on Sunday with a win against the San Francisco 49ers in what's expected to be a snowy night in Orchard Park. On the injury front, the Bills already announced prior to the game that starting tight end ...

On Saturday, the San Francisco 49ers announced the following roster moves ahead of Sunday's snowy game in Buffalo against the Bills: Promoted CB Nick McCloud