Tasked with presenting thousands of unique antigens to T cells, the proteins that form the major histocompatibility complex arise from genes on the human leukocyte antigen (HLA) locus—the most ...

Several studies have demonstrated an apparent link between positive selection on hematopoietic cells (HCs) and an "innate" T-cell phenotype. Whereas conventional CD8+ T cells are primarily selected on ...

It is now well known that SARS-CoV-2, the virus that causes COVID-19, can mutate to evade vaccine protection against infection. The Omicron variants — BA.1, B1.1 and BA.2 — can infect those who were ...

Targeted therapies specifically attach to and hinder cancer-causing proteins, but cancer cells can quickly evolve to thwart their action. A second drug class, immunotherapies, harnesses the immune ...