Nature

MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells

Major histocompatibility complex (MHC) class II–restricted antigen presentation is essential for the function of dendritic cells (DCs). We show here that plasmacytoid DCs (pDCs) differ from all other ...
Nature

Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

CD4 + T lymphocytes recognize antigenic peptides presented by major histocompatibility complex (MHC) class II molecules on the surface of antigen-presenting cells (APCs). These peptides are derived ...
Nasdaq

Gritstone Oncology Announces Oral Presentation on MHC Class II Antigen Prediction at the AACR Annual Meeting in April 2019

EMERYVILLE, Calif., Feb. 27, 2019 (GLOBE NEWSWIRE) -- Gritstone Oncology, Inc. (Nasdaq:GRTS), a clinical-stage biotechnology company developing the next generation of cancer immunotherapies to fight ...
EurekAlert!

A missing link in the MHC class divergence puzzle: Class II came first

Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health ...
ascopubs.org

Major Histocompatibility Complex Class II and Programmed Death Ligand 1 Expression Predict Outcome After Programmed Death 1 Blockade in Classic Hodgkin Lymphoma

Prostate Cancer Screening and the Goldilocks Principle: How Much Is Just Right? In this study, we assessed the possible predictive value of 9p24.1/PD-L1/PD-L2 genetic alterations and PD-L1 expression ...
ascopubs.org

Combination of paclitaxel and LAG3-Ig (IMP321), a novel MHC class II agonist, as a first-line chemoimmunotherapy in patients with metastatic breast carcinoma (MBC): Interim ...

Analysis of everolimus starting dose as prognostic marker in HR+ mBC patients treated with everolimus (EVE) + exemestane (EXE): Results of the 3rd interim analysis of the non-interventional trial ...
The American Journal of Managed Care

MHC-II May Be Predictor of Immunotherapy Response in HR+, Triple-Negative Breast Cancers

The study, according to the researchers, is the first to demonstrate the potential use of major histocompatibility complex class II (MHC-II) expression as a predictor of immunotherapy response in ...
EurekAlert!

MHC class II transactivator CIITA induces cell resistance to Ebola Virus and SARS-like coronaviruses

August 27, 2020 (Seattle, Wash.)--Discoveries from the Benaroya Research Institute at Virginia Mason (BRI) have identified a new cellular protection pathway that targets a common vulnerability in ...
WNDU

Medical Moment: Child with MHC Class II deficiency receives life-saving treatment

(WNDU) - Genetic disorders are caused by an abnormality in a person’s DNA. 10 out of 1,000 babies born will be diagnosed with one. In fact, 17% of couples are at a high risk of transmitting a genetic ...
technologynetworks

ProImmune Introduces ProT2 MHC Class II Tetramer Reagents

ProImmune’s offering represents the broadest choice of ready to order catalog and custom items in this field and will enable research into CD4+ T cell responses in a variety of disease areas including ...
JSTOR Daily

The Chicken Major Histocompatibility Complex (MHC): Evolutionary Conserved Class I and Class II Genes Are Closely Associated with Non-MHC Genes

The chicken major histocompatibility complex (chicken MHC or B complex), at present the most extensively characterized non-mammalian MHC, differes from its human and rodent counterparts in its overall ...