Intramolecular hydrofunctionalization encompasses a suite of reactions in which a nucleophilic X–H bond within a molecule adds across an unsaturated carbon–carbon bond to form cyclic architectures.

In 1887, chemist Sir Arthur Michael reported a nucleophilic addition reaction to the β-position of α,β- unsaturated carbonyl compounds. These reactions, named Michael addition reactions, have been ...

This process generates a radical cation that initiates the intramolecular C (sp 3)–N bond forming reaction. "HFIP is a fascinating yet intriguing solvent with unique physicochemical properties, that ...