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Colts vs. 49ers prediction: Indianapolis and San Francisco do battle with playoff positioning on the line

In the final game of what has been a wild Week 16, the Indianapolis Colts host the San Francisco 49ers on "Monday Night Football." The Colts come into this game starting 44-year-old Philip Rivers at quarterback after the season-ending Achilles injury to Daniel Jones.

· 21h · on MSN

Colts playoff picture: Scenarios, chances for Indianapolis to make postseason

USA TODAY Touchdown Wire on MSN · 8h

Indianapolis Colts updated playoff chances heading into Week 17

· 21h

San Francisco 49ers vs Indianapolis Colts recap today: Purdy's huge night buries Colts

Philip Rivers starts strong, but the Indianapolis Colts can't keep up in a 48-27 loss to the San Francisco 49ers.

· 20h

The Bills, Jaguars and Chargers are headed to the playoffs after the Colts' 5th straight loss

· 20h

Here are updated playoff scenarios for Seahawks heading into Week 17

· 21h

NFL Playoff Bracket Scenarios 2025-26 Week 17, Latest Standings After 49ers vs. Colts

Kyle Shanahan's team moved to 11-4 with their win over the Indianapolis Colts.

· 21h

Brock Purdy's career-high five TD passes power 49ers past Philip Rivers' Colts on 'Monday Night Football'

· 14h

3 players to blame for Colts MNF loss to 49ers

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Colts Wire on MSN · 10h

2 Indianapolis Colts players make 2026 NFL Pro Bowl roster

Two Indianapolis Colts players were named 2026 NFL Pro Bowlers.

USA TODAY Touchdown Wire on MSN · 5h

Indianapolis Colts move up in Week 17 NFL power rankings despite loss

· 1d · on MSN

NFL expert picks today against the spread: Indianapolis Colts go with Philip Rivers again

· 17h

Purdy matches Montana to keep 49ers title bid alive

Quarterback Brock Purdy threw a career-high five touchdown passes as the San Francisco 49ers beat the Indianapolis Colts 48-27 to keep their NFC West title hopes alive.

· 6h

Brock Purdy’s five touchdowns sets up absolutely chaotic NFC playoff race finish

· 20h

Brock Purdy throws career-high five touchdowns as 49ers roll over Colts

· 17h

Brock Purdy throws five TDs as 49ers outgun Colts in 48-27 scoreboard bonanza

Purdy finished with five touchdown passes, a new career high, to four different players.

· 20h

49ers punter Thomas Morstead hilariously keeping busy after punt-less month of December

· 20h

Winners and losers as 49ers outlast Philip Rivers, Colts 48-27 on Monday night

8hon MSN

How the Indianapolis Colts Got Here and Now What?

Indianapolis Colts lose to the San Francisco 49ers and now are lost moving forward in the AFC South and AFC Conference.

Monday Night Football: San Francisco 49ers vs Indianapolis Colts

This week’s Monday Night Football features the San Francisco 49ers visiting the Indianapolis Colts. The 49ers are 10-4, but in third place in a hyper-competitive NFC West. They have three games to move up the rankings.

16hon MSN

The 7 Biggest Takeaways From the 49ers' Win Against Indianapolis

Another win stacked up by the San Francisco 49ers. Their offense lit up the Indianapolis Colts in primetime to get the win with a score of 48-27. It was amazing

1don MSN

New president announced for Indianapolis City-County Council

The change comes after Council President Vop Osili announced earlier this month that he would not run again for the council's top post after eight years in the role.

WISH-TV on MSN

Downtown Indianapolis bar raises age limit to from 21 to 30

Georgia Street Rhythm & Blues Lounge in Indianapolis now restricts entry to those 30 and older, aiming to create a more mature bar environment.

1don MSN

23-year-old man killed in northwest Indianapolis shooting

INDIANAPOLIS — A man is dead after an early morning shooting on Indianapolis' northwest side Saturday. The shooting was reported just after 2 a.m. Dec. 20 in the 3900 block of Bonn Drive, which is just northwest of West 38th Street and Guion Road.