RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department ...

A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis ...

Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these ...

Cancer cells often use epigenetic changes to resist treatment, a major factor particularly in late-stage deaths from ovarian cancer. One potential epigenetic marker, DNA secondary structures known as ...

J.L. Huppert and S. Balasubramanian, "G-quadruplexes in promoters throughout the human genome," Nucleic Acids Res, 35:406–13. (Cited in 56 papers) University of Cambridge computational biologists ...

Breast cancer is the most frequent malignancy among women worldwide, and all subtypes of breast cancer involve upregulation of the c-Myc gene, making it a compelling therapeutic target. G-rich regions ...

AMES, Iowa – A research team including Iowa State University and United States Department of Agriculture - Agricultural Research Service (USDA-ARS) personnel has identified genetic structures in corn ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

As one of the inventors of next-generation DNA sequencing, Sir Shankar Balasubramanian could claim to be responsible for a revolution in the life sciences. Balasubramanian and chemist David Klenerman, ...

Paras Gaur, a postdoctoral researcher at the University of Iowa, investigates DNA damage repair and G-quadruplex structures ...