The binding sites that guide fungal 'vesicle hitchhiking'—new study maps mRNA transport

A specific protein controls mRNA transport in fungi and distinguishes important from unimportant binding sites in the ...
Science Daily

Researchers develop AI model that predicts the accuracy of protein--DNA binding

A new artificial intelligence model can predict how different proteins may bind to DNA. A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how ...
Kaleido Scope

Simplified redesign of proteins to improve ligand binding

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...
GEN

Revealing Protein-Ligand Interactions Using AI Enables Drug Discovery

Hundreds of protein-ligand interactions have been identified through a collaboration between the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Pfizer. Georg ...
EurekAlert!

Expanding the sequence spaces of synthetic binding protein using deep learning-based framework ProteinMPNN

Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...
Mirage News

New Study Describes MRNA Transport In Fungi

A specific protein controls mRNA transport in fungi and distinguishes important from unimportant binding sites in the ...
EurekAlert!

The functions of actin-binding proteins are regulated by the flexibility and specific helical twists of actin filaments

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical structure ...