Multiple sclerosis (MS) causes damage to the myelin sheath, which is the thin membrane that protects the central nervous system (CNS). Systemic sclerosis (SS) causes thickening and hardening of the ...

Multiple sclerosis isn’t inherited, but having a family member with the disease can increase your chance of having the condition. While genetics influences your risk, environmental factors also play a ...

The Marburg variant of multiple sclerosis is extremely rare but also the most severe. Life expectancy has been weeks or months, but advances in treatment have led to an improved outlook. Multiple ...

The CD40–CD40L costimulatory pathway regulates adaptive and innate immune responses and has been implicated in the pathogenesis of multiple sclerosis. Frexalimab is a second-generation anti-CD40L ...

In the human brain, neurofilament light chain (NfL, shown in brown) is seen in brain cells and the neural wires that connect them. UCSF researchers found NfL in the bloodstream of patients who would ...

The monoclonal antibody ublituximab enhances antibody-dependent cellular cytolysis and produces B-cell depletion. Ublituximab is being evaluated for the treatment of relapsing multiple sclerosis. In ...

Professional societies of neurologists, including most prominently the American Academy of Neurology (AAN) and the European Academy of Neurology (EAN) periodically release recommendations to guide ...

Here we describe the use of CAR T therapy to treat multiple sclerosis in mice. Previous installments discuss the fundamentals of CAR T and its applications for B cell cancers, multiple myeloma, lupus, ...

Multiple sclerosis (MS) is a chronic, disabling, inflammatory disease that damages your nerves. People with MS typically live roughly seven years less than the general population, with an average life ...