DEAR MAYO CLINIC: I have heard that sometimes people have gallstones and don't even know it, while others have severe pain because of them. Am I at greater risk if some of my family members have had ...

Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota. However, the underlying mechanisms ...

I have a patient with gallstones. His alkaline phosphatase is 1800 (probably due to stones in the common bile duct [CBD]) and bilirubin is normal. What would be the best approach for management of ...

The gallbladder is a small, grape sized, organ attached to the digestive tract. It secretes a fluid called bile into it in response to a meal. Bile emulsifies dietary fats by increasing their exposure ...

The gallbladder stores bile, a digestive fluid. It contracts after emptying as part of the digestive process, but other factors, such as gallstones, can cause it to collapse, leading to pain and other ...

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Diabetics face grave risks from untreated gallstones, potentially leading to severe infections or gallbladder rupture. Nerve damage from high blood sugar can mask pain, allowing conditions to worsen ...

(A) ABC transporters: The normal functioning of ABCG8/ABCG5, ABCB4, and ABCB11 enables the transport of cholesterol, bile acids, and lipids into bile (left). Mutations in any of these result in ...

Eating more fruits and vegetables can help prevent gallstones. You should avoid foods high in saturated and trans fats to lower gallstone risk. Drinking too many sugar-sweetened beverages can increase ...

The presence of gallstone disease may be a harbinger of pancreatic ductal adenocarcinoma (PDAC), researchers suggest after showing an association between the two in a SEER-Medicare database analysis.