Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both because it is difficult to treat and because of its high mortality rate. In ...

PHILADELPHIA – New antibiotic candidates for drug-resistant bacteria may reside inside prions, mis-folded protein in the brain best known for rare and fatal degenerative brain diseases. Prion and ...

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

A study from Bochum describes a mammal-specific domain of the prion protein and offers new approaches for research into neurodegenerative diseases. Prion diseases are progressive and invariably fatal ...

Prions, mysterious shape-shifting proteins, can lead to brain disorders such as Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, "mad cow disease" in cattle, yet they can also ...

CHARM – a novel molecular tool – can turn off disease-causing genes, such as the prion protein gene. Researchers at the Broad Institute of MIT and Harvard have collaborated with the Whitehead ...

Prion diseases are fatal neurodegenerative disorders characterised by the conversion of the normal cellular prion protein (PrPC) into a misfolded, β-sheet-rich isoform (PrPSc) that aggregates into ...

A study from Bochum describes a mammal-specific domain of the prion protein and offers new approaches for research into neurodegenerative diseases. At first, they cause memory deficits and ...

Researchers in a laboratory established to find a treatment for prion diseases are announcing that they have made a step forward in mice. Collaborating with a genome-editing lab, they have developed a ...

Prion diseases are a group of rare infectious neurodegenerative diseases caused by modifications in the prion protein (PrP) that prompt it to misfold. 1 Invariably fatal, prion disease can be genetic, ...