In unstimulated cells, the state of G alpha (orange circles) is defined by its interaction with GDP, G beta-gamma (purple circles), and a G-protein-coupled receptor (GPCR; light green loops). Upon ...

Alpha-1 adrenergic receptors (α1-ARs) are a subset of G protein-coupled receptors that play a pivotal role in cardiovascular homeostasis. While traditionally recognised for their involvement in ...

Finnish drugmaker Orion Corporation has announced that its candidate ODM-105 (tasipimidine) did not meet the primary goal in the Phase II UNITAS study for the treatment of patients with insomnia.

Fc receptors (FcRs) are a group of glycoproteins that belong to the immunoglobulin superfamily and are classified, like Fc alpha receptors (FcαRs), Fc gamma receptors (FcγRs) and Fc epsilon receptors ...

A compound comprising five agonists that together tackle weight loss, glucose reduction, insulin sensitization, and blood fat ...

For years, the pancreas has been being taught in biology class as an easy system: insulin lowers blood sugar, and glucagon ...

Doxazosin, a drug commonly prescribed to help improve urinary flow in men with enlarged prostates, increases the likelihood of heart failure by blocking specific receptors in heart muscle cells, ...

In a recent study posted to the bioRxiv* preprint server, researchers profiled the binding sites of the entire severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein sequence.

Substantial basic science and clinical evidence suggests that excess tumor necrosis factor-alpha (TNF-alpha) is centrally involved in the pathogenesis of Alzheimer's disease. In addition to its ...

Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients (pts) with recurrent ovarian carcinoma. Background: Farletuzumab (MORAb-003) is a ...