In a study published in Science, researchers at Karolinska Institutet describe the neural processes behind how morphine relieves pain. This is valuable knowledge because the drug has such serious side ...

Mount Sinai researchers, in collaboration with scientists at The Rockefeller University, have uncovered a mechanism in the brain that allows cocaine and morphine to take over natural reward processing ...

Opioids, including morphine, are frequently used for managing chronic pain. However, long-term use of morphine leads to tolerance, resulting in reduced analgesic efficacy. Long-term use of analgesics ...

Repeated administration of morphine renders animals tolerant to the drug and hypersensitive to pain. These two effects are strikingly similar to those induced by nerve injury. Researchers have ...

The availability of nalorphine,§ an effective morphine antagonist, has allowed a new approach to the problem of the mechanism by which this increase in intracranial pressure occurs. The following work ...

Opioid compounds disrupt sleep through their action on central mu-opioid receptors within key sleep–wake circuits and circadian centres. Activation of these receptors in regions such as the ...

Researchers at the University of Alabama at Birmingham and Baylor College of Medicine, Houston, Texas, now have shown that blocking the activity of an enzyme called Tiam1 in certain spinal neurons ...

Since the beginning of time, humanity has searched for drugs that can relieve pain without sparking addiction or the other devastating problems tied to opioids. It’s still very early, but a UC ...

Researchers describe the neural processes behind how morphine relieves pain. This is valuable knowledge because the drug has such serious side effects. In a study published in Science, researchers at ...