In a decades-long effort, researchers have discovered how to tweak the molecular pathways that turn heart muscle motors up or ...

Since the 1950s, scientists have had a pretty good idea of how muscles work. The protein at the centre of the action is myosin, a molecular motor that ratchets itself along rope-like strands of actin ...

Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity, and ...

The novel cardiac myosin inhibitor aficamten improved peak oxygen uptake in symptomatic obstructive hypertrophic cardiomyopathy (HCM), the pivotal SEQUOIA-HCM trial showed. At 24 weeks, the mean ...

Actomyosin is a protein complex composed of actin and myosin. It is found in muscle fibers where it plays a role in muscle contraction. Actin is one of the most abundant proteins in eukaryotes. It ...

Cells use the polymerization of actin alone to create some types of movement, but many other forms of movement require interplay between actin and an enzyme called ...