Thus, although most clinicians have agreed that visual outcomes in MOGAD would be much better than that in AQP4-positive optic neuritis, it was not scientifically evidenced-based on data with a ...

This disorder overlaps with both AQP4-IgG–seropositive NMOSD and multiple sclerosis, both of which also can cause optic neuritis or myelitis. 26 Patients with NMOSD clinical syndromes generally ...

Initial trigger: an unknown trigger activates the mature B-cells to produce aquaporin-4 immunoglobulin antibodies (AQP4-IgGs) AQP4-IgG penetration: AQP4-IgGs enter through the blood-brain barrier ...

NMO can cause optic neuritis and myelitis. ... Doctors will first rule out other possible conditions, then make a diagnosis based on whether a person tests AQP4-positive.

Among patients with AQP4-NMOSD, those with cardiovascular comorbidities exhibited higher annual optic neuritis relapses than those with autoimmune comorbidities (mean, 1.06 ± 3.33 vs 0.49 ± 0.98 ...

To understand the prevalence and quality of asymptomatic optic nerve enhancement, Shah and colleagues recently performed a retrospective study of AQP4-IgG–seropositive patients diagnosed with ON ...

Case 2: Bilateral optic neuritis and myelitis A 20-year-old man was PCR positive for SARS-CoV-2 with minor respiratory symptoms. He had a history of personality disorder and substance abuse.

Optic neuritis (ON) occurs when the optic nerve becomes irritated or inflamed, which can lead to the loss of its myelin sheath insulation. “Without normal insulation, the nerve doesn’t ...

Optic neuritis is a common symptom of multiple sclerosis (MS) that affects your eyes and vision. Learn more about the symptoms, causes, diagnosis, treatment, and complications of optic neuritis.