Background: In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests ...
Optic neuritis (ON) is an inflammation that damages your optic nerve. It can cause vision loss and pain when you move your eyes. As the inflammation goes away, your symptoms usually get better.
have better long-term visual outcomes than those with anti-aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMSOD), but similar to those with multiple sclerosis.
In this Healio Video Perspective from Hawaiian Eye 2025, Riad Sherif, MD, CEO of Oculis, discusses data on OCS-05 for the ...
Naismith et al. state that they preferentially recruited patients with severe optic neuritis (with ≤20/200 vision) and poor recovery (to <20/40 vision).This bias in selecting study participants ...
OCS-05 demonstrates safety and efficacy in treating acute optic neuritis, receiving FDA IND clearance for clinical development in the U.S. Small sample size of only 36 patients in the Phase 2 ...
ON = optic neuritis; OND = other neurological diseases Table 2. Clinical findings, AQP4-Ab status in serum and CSF, and median AQP4-Ab serum titres in the various disease groups.
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