Here are the three biggest takeaways for the Philadelphia 76ers following a road loss to the Indiana Pacers on Saturday.

Unorthodox lineups and the loss of starters due to injury have the Sixers reeling in the midst of a road trip.

Instead of Drummond or Bona, Sixers head coach Nick Nurse then opted to use Pete Nance at center. Nance hit a three on his first touch and the Sixers rather improbably made a 10-0 run. A Council slam trimmed the Pacers’ advantage to 106-100.

Kelly Oubre Jr. had 18 points and eight rebounds, Adem Bona had a breakout game with 11 points and six rebounds off the bench, and Andre Drummond had eight in his return from injury. Ricky Council IV had 18 points and nine rebounds. Here are the player grades following the loss:

For the first time since early December, the Sixers are 10 games below .500. The Pacers knocked off Philadelphia 115-102 Saturday night as they once again found themselves very shorthanded. Not only did Joel Embiid remain out,