Jauan Jennings of the San Francisco 49ers celebrates with fans after scoring a touchdown reception against the New Orleans Saints during the second half in the game at Caesars Superdome on September 14, 2025 in New Orleans, Louisiana.

In the New Orleans Saints' first two games under rookie coach Kellen Moore, they had a chance to win at home on their final possession —

The San Francisco 49ers and New Orleans Saints meet Sunday in Week 2 at Caesars Superdome in New Orleans, Louisiana.

Who's in, who's out? The New Orleans Saints announced their list of inactive players for Week 2's home game with the San Francisco 49ers:

Week 2 is here, and the New Orleans Saints (0-1) are playing again at home and about take on a familiar foe in the San Francisco 49ers (1-0) With kickoff just minutes away, let’s take a look at today’s inactives.

Progress easily was identifiable for the New Orleans Saints in their second regular-season game under first-year coach Kellen Moore, against San Francisco on Sunday in the Caesars Superdome. Now, the matter is making enough of it to produce victory.

Sunday, September 14thTime: 1:00 p.m. ETTV Channel: Fox Live Stream: fuboTV (watch for free) The San Francisco 49ers

NEW ORLEANS — The Saints had two chances in the final five minutes, but came up short, losing their second straight game to open the 2025 season, 26-21 to the San Francisco 49ers. The Kellen Moore era begins with New Orleans now 0 – 2. Here's what media from around the nation are saying about the Saints' second loss of the season: