Major U.S. stock indexes finished in the red Wednesday, after investors waded through a slew of economic data and some disappointing corporate financial updates ahead of the Thanksgiving Day holiday.

The S&P 500 and the Nasdaq edged lower on Wednesday, weighed by a decline in technology stocks, while investors focused on the Federal Reserve's next move following an in-line inflation reading. A Commerce Department report showed the Personal Consumption Expenditure index,

NASDAQ is losing ground amid pullback in tech stocks. Autodesk, which is down by 8.7%, is the worst performer in the NASDAQ index today. The stock found itself under pressure after the company released a solid Q3 report but announced a change of CFO.