The model is also backing Iowa (+6.5) to cover the spread on the road against USC, while the Over (52.5) hits 58% of the time in TCU vs. BYU. Before locking in your Week 12 college football picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model.

The Hawkeyes' offense nearly pulled off another late-game drive, but it was a third-quarter sequence that really was costly in a loss at USC.

After taking a 21-7 lead in the second quarter, Iowa was outscored 19-0 to close the game. The Hawkeyes blew the 14-point cushion on their way to a 26-21 loss to USC, adding to what has been a season defined by frustratingly slim margins.

The No. 21 Iowa Hawkeyes, led by quarterback Mark Gronowski, face the No. 17 USC Trojans, led by quarterback Jayden Maiava on Saturday, Nov. 15, 2025 at Los Angeles Memorial Coliseum in Los Angeles, Calif.

Some of the numbers don't stand out. He's made a few mistakes. Yet, there's a real case to make that Jayden Maiava is the best QB in college football

We have a loaded slate of college football games set to take place today, with plenty of them being extremely important when it comes to shaping the postseason

The No. 17 ranked USC Trojans face the No. 21 Iowa Hawkeyes hoping to avoid an upset at home in this intriguing Big Ten showdown between Top ranked 25 foes.

Find out why Geoff Schwartz believes an upset is brewing in L.A. and why he's backing UW to cover the big spread against Purdue in CFB Week 12.