Former Buffalo Bills (and current San Francisco 49ers) defender Leonard Floyd will be facing off against his old club this ...

The Buffalo Bills have opened the 21-day practice windows of offensive tackle Tylan Grable and defensive tackle DeWayne ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

The Bills appear to be getting closer to getting a key piece of their defense on the field for the first time this season.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

The Buffalo Bills will host the San Francisco 49ers in a somewhat hostile environment. Sean McDermott knows how to handle ...

There is a high Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the 49ers (5-6) and the ...

Tight end Dalton Kincaid was held out with a knee injury Wednesday as the Bills returned to practice following their bye week. Right tackle Spencer Brown (ankle) and ...

Orchard Park, N.Y. (WHAM) — Bills rookie running back Ray Davis has always searched for a place to call home. "I didn't live ...

Buffalo Bills team reporter Maddy Glab joins 1st & 10 to breakdown the 49ers-Bills matchup, discuss what to expect on "SNF" ...

How do the Bills believe they will ever get to the more than 5,000 potential season ticket holder accounts on their waitlist ...